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Medical > Ischemia

The following information is about Ischemia.

Ischemia Defined

A condition in which a tissue or organ does not receive a sufficient supply of blood

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Off-site Ischemia Links, User Submitted

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  • Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression -- Cordeiro et al. 295 (1): H154 -- AJP - Heart and Circulatory Physiology: Endo and Epi differences in transient outward K+ current and/or ATP-sensitive K+ channel current are believed to contribute to the differential response. The present study tested the hypothesis that the greater sensitivity of Epi is due in part to its functionally distinct early fast Na+ current (INa). APs were recorded from isolated Epi and Endo tissue slices and coronary-perfu sed wedge preparations before and after exposures to elevated extracellular K+ concentration ([K+]o; 6?12 mM). INa was recorded from Epi and Endo myocytes using whole cell patch-clamp techniques. In tissue slices, increasing [K+]o to 12 mM reduced Vmax to 51.1 ± 5.3% and 26.8 ± 9.6% of control in Endo (n = 9) and Epi (n = 14), respectively (P < 0.05). In wedge preparations (n = 12), the increase in [K+]o caused selective depression of Epi APs and transmural conduction slowing and block. INa density was not significantly different between Epi (n = 14) and Endo (n = 15) cells, but Epi cells displayed a more negati

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