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Off-site Endothelium Links, User Submitted

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Thu Jun 25

• CD151 Regulates Tumorigenesis by Modulating the Communication between Tumor Cells and Endothelium ? Mol Cancer Res: 231 cells interaction with endothelial cells - huvec stimulate 231 invasion in 3D cultures. CD151 is important for this, but EGF may not be - perhaps HRG?

Wed Jun 24

• ScienceDirect - Current Opinion in Pharmacology : Neuregulin-1/E rbB signaling: a druggable target for treating heart failure: some info on NRG and ErbBs in heart - B2/B4 in cardiac cells, B3/B2 in the 'cushion& #039;/stroma between endothelium and cardiac cells, and NRG produced by endothelial cells. Also describe using recombinant NRG iv

Mon Apr 13

• Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration -- Iwaguro et al. 105 (6): 732 -- Circulation

Tue Apr 7

• The Two Faces of Endothelial Nitric Oxide Synthase in the Pathophysiolog y of Atherosclerosi s - Endothelium: Journal of Endothelial Cell Research: The two faces of endothelial nitric oxide synthase in the pathophysiolog y of atherosclerosi s. Kawashima S. Endothelium. 2004 Mar-Apr

Wed Apr 1

• Modular control of endothelial sheet migration ? Genes & Development: screen of molecules contributing to wound healing, identification of modules

Mon Mar 23

• Vascular Disease in Mice With a Dysfunctional Circadian Clock -- Anea et al. 119 (11): 1510 -- Circulation: Cardiovascular disease is the leading cause of death for both men and women in the world. A profound pattern exists in the time of day at which the death occurs; it is in the morning, when the endothelium is most vulnerable and blood pressure surges, that stroke and heart attack most frequently happen. Although the molecular components of circadian rhythms rhythmically oscillate in blood vessels, evidence of a direct function for the "circadia n clock" in the progression to vascular disease is lacking. we found increased pathological remodeling and vascular injury in mice with aberrant circadian rhythms, Bmal1-knockout and Clock mutant. naive aortas from Bmal1-knockout and Clock mutant mice exhibit endothelial dysfunction. Akt and subsequent nitric oxide signaling, a pathway critical to vascular function, was significantly attenuated in arteries from Bmal1-knockout mice.
• Vascular Rhythms and Adaptation: Do Your Arteries Know What Time It Is? -- Keaney and Weaver 119 (11): 1463 -- Circulation: Editorials ? arterioscleros is ? circadian rhythm ? endothelium ? vascular injury

Wed Mar 11

• Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR ? PNAS: endothelial cells can take up EGFR through microvesicles from tumor cells! Possible explanation for CFPlabeling of endothelial cells? Could macrophages / microglia do the same?

Tue Mar 10

• ScienceDirect - Experimental Cell Research : Intra- and extracellular signaling by endothelial neuregulin-1: endothelial cells can produce heregulin and its production is stimulated by hypoxia. Could contribute to intravasation in stopped vessels?

Mon Mar 9

• Arterial endothelial dysfunction in baboons fed a high-cholester ol, high-fat diet -- Shi et al. 82 (4): 751 -- American Journal of Clinical Nutrition

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Off-site Endothelium Research Links

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