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Sat Feb 28

• Efficacy and Safety Profile of Dabigatran Etexilate Compared with Enoxaparin in Primary Venous Thromboembolis m Prevention after Total Knee or Hip Replacement Surgery in Patients Over 75 Years -- Dahl et al. 112 (11): 437 -- ASH Annual Meeting Abstracts: Dabigatran as good as Enoxaparin
• Effects of Age, Weight, Gender and Renal Function in a Pooled Analysis of Four Phase III Studies of Rivaroxaban for Prevention of Venous Thromboembolis m after Major Orthopedic Surgery -- Bauer et al. 112 (11): 436 -- ASH Annual Meeting Abstracts: Rivaroxaban better than Enoxaparin

Wed Feb 25

• Thrombophilia |:| Links to Resources

Sat Nov 15

• The ACCP Guidelines June 2008: Dabigatran (Pradaxa) A direct thrombin inhibitor, is similar to ximelagatran in that it is the prodrug of the orally bioavailable dabigatran etexilate.[20] Dabigatran binds directly to thrombin and prevents the cleavage of fibrinogen to fibrin, an essential step in thrombus formation. Dabigatran inhibits both fibrin-bound thrombin as well as circulating fibrin. Rivaroxaban (Xarelto) Offers significant management advantages over warfarin. It does not require laboratory monitoring, is dosed once a day, and to date, no drug-drug or drug-diet interactions have been identified. Nor is rovaroxaban associated with the same adverse hepatic effects that were the demise of ximlelagatran 4 years ago. The advantages of rivaroxaban are related to the drug's high selectivity for factor Xa.
• RIVAROXABAN: Factor Xa Inhibitor - Acute Coronary Syndromes (ACS), stoke prevention, instead of warfarin (post surgery)

Fri Sep 19

• Clinical Trials of Novel Anticoagulants for Severe Sepsis: A Tale of Three Molecule | LaRosa and Opal: PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation In Severe Sepsis)

Tue Sep 16

• THE INTERACTIONS OF HERBS AND DRUGS: According to one recent literature review, it was suggested that patients try to limit their vitamin K intake from their diet to 65?80 micrograms. Vitamin K is produced by intestinal bacteria; use of antibiotics that inhibit intestinal bacteria can also change the vitamin K content of the patient?s blood. Teas, pills, and other forms of herbal preparations generally have low levels of vitamin K, due to the relatively small amount of leafy tops (the main source of this vitamin) that are consumed. Still, many herbs are reputed to have anticoagulant properties that were investigated because of the importance of anticoagulatio n therapy ... In particular, the most commonly used Chinese herb for treating blood stasis in modern practice is salvia. It has been reported that salvia may enhance the warfarin effects and may cause significant changes in blood properties. Tang-kuei was also mentioned.

Thu Sep 11

• Healthnotes - VitaminShoppe. com

Sun Aug 31

• Stopping Anticoagulants 6 Months After Unprovoked VTE

Sat Jul 19

• Point-of-Care Testing InfoSite

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